Gene-modified cell therapy (GMCT) represents the most effective platform for many patients with advanced disease. These therapies, however, are held back by inefficient development processes and manufacturing scales that are limited to a minute fraction of the relevant patient populations due to current gene delivery methods such as viral vectors. Simulation is helping to accelerate this development process and advance cell therapy.
Indee Labs is a Y Combinator company spun out of the Australian National Fabrication Facility. The team is developing novel gene delivery technology that uses ANSYS computational fluid dynamics solutions to gently and efficiently deliver genetic materials such as CRISPR to your immune cells. Indee Labs views gene delivery as the most problematic step in developing and manufacturing GMCTs since a global shortage in viral vectors has led Big Pharma to invest hundreds of millions of dollars into their own manufacturing facilities. Continue reading →
Multihull ships create engineering challenges that are “out of range” of conventional ship design techniques. They require complex, CFD analysis to optimize multiple performance variables like resistance, endurance, stability, seakeeping, etc. In this article, we take you behind the scenes at KUASAR MARIN Engineering Inc., where we leveraged ANSYS Fluent to explore design iterations for a three-hulled, high-speed passenger ferry that could compete with existing two-hull catamarans.
Nature is full of amazing materials. Wood and bone, for example, are natural composites with finely-tuned microstructures. They have optimized fiber alignment for enhanced strength. At Fortify — an additive manufacturing startup — we wondered if harnessing the power of natural composites in 3-D printing could help us to create high-performance end-use parts.
Our observations of the natural world led to the development of our fluxprint technology, which utilizes magnetic fields in a 3-D printer to align carbon fibers throughout a printed composite part. This process results in high-performance components with high-geometric complexity and incredible strength-to-weight ratios. Continue reading →
A technology startup faces a great deal of challenges: funding, hiring, office space, manufacturing, messaging, legal, software, and infrastructure, to name a few. CEOs can feel overwhelmed by the sheer size and complexity of the puzzle that is establishing a successful corporation. It only takes one of the pieces to fail to jeopardize the whole enterprise. The stakes are high.
One area of investment that is particularly expensive and difficult to get right for hardware startups is the engineering simulation software and high performance computing (HPC) infrastructure required for virtual prototyping and testing. Rescale and the ANSYS Startup Program offer solutions for startups with on-demand and fully scalable software and hardware that require zero in-house IT.
Rescale and the ANSYS Startup Program are partnering to offer a scalable,
zero-IT simulation solution to startups
For over 100 years, propellers have been the propulsion method of choice for aircraft, helicopter, and boat manufacturers. With the rise of multi-rotor technology, the limitations of this ancient method of propulsion have placed a glass ceiling on emerging industries such as drone delivery and “flying cars.” Besides the obvious safety issues, the faster that a blade rotates the more inefficient it becomes at transferring energy into thrust. A key reason for this upper limit on economies of RPM is that the faster a blade spins, the more prominent the vortex geometry becomes in the mass flow, which is parasitic to propulsion. This constrains both payload and range. Continue reading →
Nuclear power is a key player in the future of clean energy, and multiple companies are pursuing new technologies to maximize nuclear’s contribution to the clean energy space. Founded in 2011 and based in Cambridge, MA, Transatomic Power is an advanced nuclear technology startup developing and commercializing a molten salt reactor (MSR), or a nuclear reactor whose fuel is in liquid, rather than solid, form. This technology, originally developed at the Oak Ridge National Laboratory (ORNL) in the 1960’s, offers multiple safety and cost benefits over traditional nuclear reactors, in which the fuel is in the form of solid pellets cooled by water.
Tranatomic’s MSR design builds on the original work at ORNL and adds a few innovative new features that reduce the reactor’s size and, as a result, it’s cost – a huge factor in building new nuclear power plants. Though the development process is a long one, the world needs a larger capacity for clean energy generation, and it’s this ultimate goal that drives the Transatomic team forward. Continue reading →
The journey of BiomeRenewables’ PowerConeTM wind turbine started with witnessing a falling maple seed. I was sitting on my deck when I was struck by how slowly the seed was able to fall. As it turns out, maple seeds — for their size — exhibit maximum aerodynamic efficiency; they are able to hit what is known as the Betz Limit — 59.3 percent aerodynamic efficiency. Careful analysis revealed that there is something about the seed’s shape and the way it interacts with the air that allows it to achieve such high efficiency numbers — namely, that it interacts with the oncoming flow at an angle greater than 90 degrees. This is not the case with modern wind turbines, which interact with the wind at perpendicular angles of 90 degrees. Continue reading →
Working for ANSYS gives me incredible opportunities to work with innovative companies and learn about the latest technologies that are being developed to improve our lives. One of the intriguing companies I have had the pleasure to work with is RF2ANTENNA. RF2ANTENNA works on developing innovative and easy-to-integrate products for specific applications in wireless communications and wireless charging, with the goal of improving the efficiency of IoT devices with affordable solutions. Their core competency is in providing solutions to radiation problems in mobile products. The ANSYS Startup Program has given them the opportunity to take their work to the next level. Continue reading →
Most people occasionally have dreams of flying — without the aid of an airplane or other mechanical device — just soaring through the air on their own power. The thrill ends with dream, unfortunately. Closer down to earth, many of us enjoy the feeling of gliding effortlessly across the snow on skis or a snowboard, over the ice on skates, or on a surfboard cutting through the water. There is something about the effortless gliding sensation that can’t be approached by the more mundane act of walking — though walking has its pleasures too.
Recent advances in 3-D printing with metal have advanced to the point where antennas and RF components can be consistently fabricated with excellent performance in the millimeter wave frequencies. Optisys is a startup based in Utah that is focused on using the most advanced simulation tools to design antennas and radio-frequency (RF) components that could not have been fabricated a few years ago. The use of 3-D printing an antenna creates orders of magnitude reduction in size, weight, and lead time. These savings are enabled through a key partnership with the ANSYS Startup Program. Continue reading →