Gene-modified cell therapy (GMCT) represents the most effective platform for many patients with advanced disease. These therapies, however, are held back by inefficient development processes and manufacturing scales that are limited to a minute fraction of the relevant patient populations due to current gene delivery methods such as viral vectors. Simulation is helping to accelerate this development process and advance cell therapy.
Indee Labs is a Y Combinator company spun out of the Australian National Fabrication Facility. The team is developing novel gene delivery technology that uses ANSYS computational fluid dynamics solutions to gently and efficiently deliver genetic materials such as CRISPR to your immune cells. Indee Labs views gene delivery as the most problematic step in developing and manufacturing GMCTs since a global shortage in viral vectors has led Big Pharma to invest hundreds of millions of dollars into their own manufacturing facilities. Continue reading →
Nature is full of amazing materials. Wood and bone, for example, are natural composites with finely-tuned microstructures. They have optimized fiber alignment for enhanced strength. At Fortify — an additive manufacturing startup — we wondered if harnessing the power of natural composites in 3-D printing could help us to create high-performance end-use parts.
Our observations of the natural world led to the development of our fluxprint technology, which utilizes magnetic fields in a 3-D printer to align carbon fibers throughout a printed composite part. This process results in high-performance components with high-geometric complexity and incredible strength-to-weight ratios. Continue reading →
Since its creation, hang gliding has progressed solely — and often painfully — through experimentation. But engineering simulation is starting to change that.
The German inventor and flight pioneer Otto Lilienthal made over 2,000 flights as long as 820 feet in gliders he designed and flew in the 1890s. He died in 1896 from injuries sustained in a glider crash, but his well-documented accounts of theories and experiences with flight influenced many of the early aviation pioneers, including the Wright Brothers. Continue reading →
Energy supply is one of the world’s biggest challenges. Fusion technology has the potential to solve this challenge by providing on-demand, safe and clean energy that will combat climate change while driving economic growth. Drawing on decades of advancements in plasma physics, materials engineering and computer simulation, General Fusion is working to develop the world’s first commercially viable fusion power plant.
What Makes the General Fusion System Different?
Developing a completely new form of energy comes with plenty of challenges and unknowns, so General Fusion utilizes milestone-driven R&D campaigns and ANSYS simulation solutions to reduce the risk in its development process. One such campaign focused on testing the liquid metal compression technology that forms the core of General Fusion’s power plant. Continue reading →
The rapid surge in consumer demand for mobility, connectivity and content has fundamentally changed the space industry. Space, as the ultimate vantage point, is a necessary destination to connect 55 percent of the world that does not have access to the internet. With miniaturization of technologies, capabilities that until now required large satellites the size of a bus with a billion-dollar price tag are being challenged by small satellites that are 12 inches long and weigh only 9 pounds. When constellations of 24 to 800 of these small satellites are established in low Earth orbit, the world will enjoy global WiFi, maritime connectivity, real-time navigation maps, precise weather forecasts, virtual reality in space and more. Continue reading →
Have you ever thought, “I love this product, but it would be even better if…”? Maybe you wish it were more durable, lighter or even more aesthetically pleasing. Perhaps if it had more features, or operated under more grueling conditions, it would better fit your needs. While you may not think about these little things very often, we at Jacobs Analytics are obsessed with these details and believe in perpetual innovation. We have taken the answers to these questions and designed things like a stronger bike frame and a colder water.
The products we use everyday make our lives easier and more efficient; and when they work well enough, we tend not to think much about them. Then one day you come across a better version and realize the product you have been using did have room for improvement, and the improved design makes your daily experience that much better. Continue reading →
Every so often I come across a great read I think is so worthwhile that I want to share it with the world. This is the feeling I got when I read Henrik Zillmer’s recent startup blog post, What Every Future Entrepreneur Needs To Know, Part 1. The only change I would make is removing the word “future” from his title because quite frankly I think ALL entrepreneurs (past, present, and future) could benefit from his words.
Of course, there are lots of articles and blog posts that make running a startup sound like the coolest and trendiest thing to do these days, but Henrik doesn’t glamorize the investment one must make to be successful when choosing this path and he gives real, useful advice. Continue reading →
If you do a quick Google search, you will find many articles and resources that offer tips on creating a solid funding pitch. For the purpose of this blog, I am referencing Chance Barnett, CEO of CrowdFunder, who has raised millions in angel and venture capital, and seen thousands of company pitches on his company’s website. (You can find all his recommendations and download his pitch deck template.)
But, I want to highlight how an entrepreneur could add simulation to their pitch deck to strengthen their message and add credibility to the proposed project. Continue reading →
AirLoom Energy (from left to right): Mookwon Seo (engineer), Olivia Lim (engineer), Robert Lumley (president), Blossom Ko (operations). Additional staff (not pictured): Lance Goode (systems administrator), Josh Hamblin (engineer)
Breakthrough energy innovation comes in many forms, as we at AirLoom Energy are proving with our revolutionary design of an alternative to the wind turbine. AirLoom Energy is a startup wind energy company housed at the incubator program (WTBC) at the University of Wyoming, home of the Cowboys football team and big, BIG wind. We were recently awarded an SBIR grant from the National Science Foundation to support the prototype development of our novel AirLoom wind power generation technology, a milestone that can be credited in large part to support received through the ANSYS Startup program. Continue reading →