Indee Labs is Simulating Its Way to Scalable Gene-modified Cell Therapy

Gene-modified cell therapy (GMCT) represents the most effective platform for many patients with advanced disease. These therapies, however, are held back by inefficient development processes and manufacturing scales that are limited to a minute fraction of the relevant patient populations due to current gene delivery methods such as viral vectors. Simulation is helping to accelerate this development process and advance cell therapy.

Indee Labs is a Y Combinator company spun out of the Australian National Fabrication Facility. The team is developing novel gene delivery technology that uses ANSYS computational fluid dynamics solutions to gently and efficiently deliver genetic materials such as CRISPR to your immune cells. Indee Labs views gene delivery as the most problematic step in developing and manufacturing GMCTs since a global shortage in viral vectors has led Big Pharma to invest hundreds of millions of dollars into their own manufacturing facilities. Continue reading

Do Trees Improve the Near-road Air Quality?

The Laboratory for Environmental Flow Modeling at the University of California, Riverside, has used ANSYS Fluent software to model a variety of environmental flows. As a third year Ph.D. candidate student in Mechanical Engineering, I recently evaluated the influence of roadside vegetation barriers on the near-road air quality using Computational Fluid Dynamics (CFD), as part of a research team that included my colleague Seyedmorteza Amini and my advisor Dr. Marko Princevac.

Exposure to traffic-related air pollution leads to public health concerns such as respiratory problems, birth and developmental defects, cardiovascular effects and cancer for people who live and work near major roadways. The near-road air quality can be improved directly by deploying vehicle emission control techniques, using alternative fuels or electric vehicles (EVs), or via passive pollutant control and roadside configuration design such as solid and vegetative barriers. Continue reading

Fast, Accurate and Reliable Turbomachinery Simulation with Harmonic Analysis – Meet me at the Turbo Expo to learn more!

Transient blade row simulations in turbomachinery are needed either to improve the aerodynamic performance predictions or because the flow interaction we are trying to resolve and predict is unsteady in nature such as aeromechanical, aerothermodynamic or aeroacoustic interactions. Because the blade pitch is not similar between the rows of turbine or compressor, a transient blade row simulation will usually require the modeling of the full wheel (or full geometry). This constraint renders these simulations not practical and in many cases prohibitive as analysis or design tools. Continue reading

Overset Mesh and CFD Simulates a Clean Room Smoke Test

clean room environmentRecent innovations in ANSYS 18 overset mesh have made it possible to use computational fluid dynamics simulations to model the smoke tests that provide useful guidance in designing clean rooms.

Ensuring Clean Rooms are Actually Clean

In the healthcare and electronics industries, process contamination is a primary concern. They manufacture these sensitive products in clean rooms where the concentration of airborne particles is controlled to specified limits. For example, a Class 100 clean room keeps particles of 0.5 microns or larger to less than 100 per cubic foot of air. Even in these controlled environments, particles are constantly being created and can settle on and contaminate surfaces and products.   Continue reading

Learn About the Many Innovative Features of ANSYS 18

I’m excited and honored to share with you the innovations in the latest release of our suite of simulation solutions, ANSYS 18, on behalf of over a thousand R&D professionals at ANSYS. The driving force for these innovations is the spread of simulation to all areas of engineering practice, a trend we call “pervasive engineering simulation.”

This trend is enabling engineers to explore the design parameter space earlier in the product lifecycle (digital exploration), test thousands of detailed designs rapidly and efficiently (digital prototyping), and monitor and optimize their product’s operation after it has been deployed (using digital twins).

To make pervasive engineering simulation as easy as possible for all engineers, we’ve added a lot of new features to each product family, as you can see below. For more information on ANSYS 18, including demo videos, webcasts, application briefs and technical papers, see our ANSYS 18 web pages. Continue reading

Get Up to Speed with ANSYS Training Options to #LearnANSYS

For over 40 years, ANSYS training has been a reliable partner for engineers to increase their productive use of ANSYS software. With tight deadlines and demanding product design requirements moving CAE engineers into the spotlight, engineers are feeling the pressure to deliver accurate predictions of product performance in a timely manner, often times before a product is even built.

Project and product success ultimately hinges on the preparedness of the engineering team to perform the simulations necessary to support key engineering decisions. In an environment of evolving demands it is becoming a high priority for engineers to keep their skills current. Successful engineers therefore focus on learning more in order to stay on top and to move ahead. Continue reading

Concept to Optimization with Upfront Simulation

Do you wish you had a way to build and test your ideas virtually before investing in physical prototypes? An easy, accurate method that accelerates design timelines and reduces costs?

We all have ideas. Product designers strive to come up with ideas for innovative products. In the modern era, most products are not simple and must fulfill multiple functions in addition to being cost-effective and stylish. A good idea for a product often means understanding how a thousand smaller ideas work together to create the whole. Unfortunately, it is expensive to physically test every idea or many versions of the best one. Fortunately, upfront simulation helps engineers optimize their product idea before building the first physical prototype. Attend our webinar to see how. Continue reading

Zyz Sailing Team Designs Using ANSYS

Zys sailing teamZyz sailing team started designing and manufacturing small sailing boats in 2008 to participate to Italian inter-university regattas called 1001velaCUP. During the first eight-year experience of the team, different boats have been launched, trying to optimize all different aspects that influence the final performance of a boat. R3 class rule adopted in this competition imposes geometrical and structural constrains to the design process: maximum length x beam of the boat is 4,60 x 2,10 m, while a minimum percentage weight for the hull constituted by 70% of plant-origin material is imposed. Continue reading

Why 10x More HPC Matters?

hpc scalibilityIn my talks with engineering managers, flow analysts and IT staff, I often hear variants of this question. Why is more computing power a strategic asset for my engineering department? Why does scalability matter for my simulation jobs that don’t go beyond 32–64 cores in parallel? What’s in it for IT when we are stuck with our current HPC server or cluster for at least two years? Let me try to answer each of these questions.
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Pay-Per-Use Licensing for Cloud Computing

ansys elastic licensingWhile considering a switch to the cloud, many of you may wonder how ANSYS licensing will work there, and more in particular, when and how we will support a pay-per-use model. I have very good news for you. Along with your existing licenses, you can use our newly announced ANSYS Elastic LicensingTM. This is a new pay-per-use licensing model unlocking virtually every ANSYS product that is supported on cloud-hosting partner hardware. Continue reading