Gene-modified cell therapy (GMCT) represents the most effective platform for many patients with advanced disease. These therapies, however, are held back by inefficient development processes and manufacturing scales that are limited to a minute fraction of the relevant patient populations due to current gene delivery methods such as viral vectors. Simulation is helping to accelerate this development process and advance cell therapy.
Indee Labs is a Y Combinator company spun out of the Australian National Fabrication Facility. The team is developing novel gene delivery technology that uses ANSYS computational fluid dynamics solutions to gently and efficiently deliver genetic materials such as CRISPR to your immune cells. Indee Labs views gene delivery as the most problematic step in developing and manufacturing GMCTs since a global shortage in viral vectors has led Big Pharma to invest hundreds of millions of dollars into their own manufacturing facilities. Continue reading →
Multihull ships create engineering challenges that are “out of range” of conventional ship design techniques. They require complex, CFD analysis to optimize multiple performance variables like resistance, endurance, stability, seakeeping, etc. In this article, we take you behind the scenes at KUASAR MARIN Engineering Inc., where we leveraged ANSYS Fluent to explore design iterations for a three-hulled, high-speed passenger ferry that could compete with existing two-hull catamarans.
Nature is full of amazing materials. Wood and bone, for example, are natural composites with finely-tuned microstructures. They have optimized fiber alignment for enhanced strength. At Fortify — an additive manufacturing startup — we wondered if harnessing the power of natural composites in 3-D printing could help us to create high-performance end-use parts.
Our observations of the natural world led to the development of our fluxprint technology, which utilizes magnetic fields in a 3-D printer to align carbon fibers throughout a printed composite part. This process results in high-performance components with high-geometric complexity and incredible strength-to-weight ratios. Continue reading →
A technology startup faces a great deal of challenges: funding, hiring, office space, manufacturing, messaging, legal, software, and infrastructure, to name a few. CEOs can feel overwhelmed by the sheer size and complexity of the puzzle that is establishing a successful corporation. It only takes one of the pieces to fail to jeopardize the whole enterprise. The stakes are high.
One area of investment that is particularly expensive and difficult to get right for hardware startups is the engineering simulation software and high performance computing (HPC) infrastructure required for virtual prototyping and testing. Rescale and the ANSYS Startup Program offer solutions for startups with on-demand and fully scalable software and hardware that require zero in-house IT.
Rescale and the ANSYS Startup Program are partnering to offer a scalable,
zero-IT simulation solution to startups
Nuclear power is a key player in the future of clean energy, and multiple companies are pursuing new technologies to maximize nuclear’s contribution to the clean energy space. Founded in 2011 and based in Cambridge, MA, Transatomic Power is an advanced nuclear technology startup developing and commercializing a molten salt reactor (MSR), or a nuclear reactor whose fuel is in liquid, rather than solid, form. This technology, originally developed at the Oak Ridge National Laboratory (ORNL) in the 1960’s, offers multiple safety and cost benefits over traditional nuclear reactors, in which the fuel is in the form of solid pellets cooled by water.
Tranatomic’s MSR design builds on the original work at ORNL and adds a few innovative new features that reduce the reactor’s size and, as a result, it’s cost – a huge factor in building new nuclear power plants. Though the development process is a long one, the world needs a larger capacity for clean energy generation, and it’s this ultimate goal that drives the Transatomic team forward. Continue reading →
The journey of BiomeRenewables’ PowerConeTM wind turbine started with witnessing a falling maple seed. I was sitting on my deck when I was struck by how slowly the seed was able to fall. As it turns out, maple seeds — for their size — exhibit maximum aerodynamic efficiency; they are able to hit what is known as the Betz Limit — 59.3 percent aerodynamic efficiency. Careful analysis revealed that there is something about the seed’s shape and the way it interacts with the air that allows it to achieve such high efficiency numbers — namely, that it interacts with the oncoming flow at an angle greater than 90 degrees. This is not the case with modern wind turbines, which interact with the wind at perpendicular angles of 90 degrees. Continue reading →
Since its creation, hang gliding has progressed solely — and often painfully — through experimentation. But engineering simulation is starting to change that.
The German inventor and flight pioneer Otto Lilienthal made over 2,000 flights as long as 820 feet in gliders he designed and flew in the 1890s. He died in 1896 from injuries sustained in a glider crash, but his well-documented accounts of theories and experiences with flight influenced many of the early aviation pioneers, including the Wright Brothers. Continue reading →
Energy supply is one of the world’s biggest challenges. Fusion technology has the potential to solve this challenge by providing on-demand, safe and clean energy that will combat climate change while driving economic growth. Drawing on decades of advancements in plasma physics, materials engineering and computer simulation, General Fusion is working to develop the world’s first commercially viable fusion power plant.
What Makes the General Fusion System Different?
Developing a completely new form of energy comes with plenty of challenges and unknowns, so General Fusion utilizes milestone-driven R&D campaigns and ANSYS simulation solutions to reduce the risk in its development process. One such campaign focused on testing the liquid metal compression technology that forms the core of General Fusion’s power plant. Continue reading →
The rapid surge in consumer demand for mobility, connectivity and content has fundamentally changed the space industry. Space, as the ultimate vantage point, is a necessary destination to connect 55 percent of the world that does not have access to the internet. With miniaturization of technologies, capabilities that until now required large satellites the size of a bus with a billion-dollar price tag are being challenged by small satellites that are 12 inches long and weigh only 9 pounds. When constellations of 24 to 800 of these small satellites are established in low Earth orbit, the world will enjoy global WiFi, maritime connectivity, real-time navigation maps, precise weather forecasts, virtual reality in space and more. Continue reading →
Have you ever thought, “I love this product, but it would be even better if…”? Maybe you wish it were more durable, lighter or even more aesthetically pleasing. Perhaps if it had more features, or operated under more grueling conditions, it would better fit your needs. While you may not think about these little things very often, we at Jacobs Analytics are obsessed with these details and believe in perpetual innovation. We have taken the answers to these questions and designed things like a stronger bike frame and a colder water.
The products we use everyday make our lives easier and more efficient; and when they work well enough, we tend not to think much about them. Then one day you come across a better version and realize the product you have been using did have room for improvement, and the improved design makes your daily experience that much better. Continue reading →